376716514ENSG00000187486ENSMUSG00000096146Q14654Q61743NM_000525NM_001166290NM_001377296NM_001377297NM_001204411NM_010602NP_000516NP_001159762NP_001364225NP_001364226NP_001191340NP_034732Kir6.2 is a major subunit of the ATP-sensitive K+ channel, a lipid-gated inward-rectifier potassium ion channel.

The protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor (SUR) to constitute the ATP-sensitive K+ channel.

Mutations in this gene are a cause of congenital hyperinsulinism (CHI), an autosomal recessive disorder characterized by unregulated insulin secretion.

[7] Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM).

[5][8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.