Lick Run begins in a valley in Jordan Township, Lycoming County.

It flows nearly due south for almost a mile, in the process exiting Jordan Township and Lycoming County.

A short distance further downstream, the stream reaches its confluence with Little Fishing Creek.

[1] Lick Run joins Little Fishing Creek 12.02 miles (19.34 km) upstream of its mouth.

[5] Lick Run was entered into the Geographic Names Information System on August 2, 1979.

[6] A prestressed box beam bridge carrying Pennsylvania Route 42 over Lick Run was built in 1987.