Lipidology

[1][2][3] Clinical studies on lipid metabolism in the body have led to developments in therapeutic lipidology for disorders such as cardiovascular disease.

[4] Compared to other biomedical fields, lipidology was long-neglected as the handling of oils, smears, and greases was unappealing to scientists and lipid separation was difficult.

[5] The field was further popularized following the cytologic application of the electron microscope, which led scientists to find that many metabolic pathways take place within, along, and through the cell membrane - the properties of which are strongly influenced by lipid composition.

These are often seen at higher than expected and necessary levels in the body due to food uptake, family history, and a person's metabolic rate.

Pharmacologic inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), an enzyme crucial for maintaining lipoprotein homeostasis, can be achieved through the use of monoclonal antibodies targeting PCSK9, such as evolocumab and alirocumab.