[7] The MIF protein superfamily also includes a second member with functionally related properties, the D-dopachrome tautomerase (D-DT).

[18][19][20] MIF plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids.

[20][21][22] This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate a role in integrin signaling pathways.

[26] Macrophage migration inhibitory factor has been reported to interact with: MIF is a potential drug target for sepsis, rheumatoid arthritis, and cancer.

[42][43] A preclinical study showed that blocking parasite MIF improves outcome in severe protozoan infections.