Slater-Marietta is a census-designated place (CDP) in Greenville County, South Carolina, United States, along the North Saluda River.

J. Harvey Cleveland, born in 1815, invested in land in northern Greenville County, including a 300-acre (1.2-million m2) tract along the North Saluda River which he bought from his father-in-law about 1840.

He also plotted a nearby settlement, named "Marietta" after his wife, Mary Louisa Williams.

[6] Though in an otherwise favorable location, the resulting village was slow to grow, possibly because the only direct access to the area was via the dangerous Jones Gap Road.

The CK&W rail line that became nicknamed the Swamp Rabbit was laid past Marietta in the late 1880s.

[7] The new Slater Mill opened in 1928, was very successful, and overwhelmed the two communities, which became referred to as Slater-Marietta.

South Carolina Highway 288 leads west from Marietta 9 miles (14 km) to Pumpkintown.

[5] As of the 2020 United States census, there were 2,087 people, 673 households, and 408 families residing in the CDP.