Mozambique competed at the 2022 Commonwealth Games at Birmingham, England from 28 July to 8 August 2022.

[1] It was Mozambique's seventh appearance at the Games.

Caio Lobo and Alcinda Panguana were the country's flagbearers during the opening ceremony.

[2] The following is the list of number of competitors participating at the Games per sport/discipline.

A squad of three judoka was entered as of 6 July 2022.