Mueang Sisaket (Thai: เมืองศรีสะเกษ, RTGS: Mueang Si Sa Ket, pronounced [mɯ̄a̯ŋ sǐː sàʔ kèːt]) is the capital district (amphoe mueang) of Sisaket Province, northeastern Thailand.

The district was renamed from Klang Si Sa Ket (กลางศีร์ษะเกษ) to Mueang Sisaket in 1913.

[3] Neighboring districts are (from the north clockwise) Yang Chum Noi, Kanthararom, Nam Kliang, Phayu, Wang Hin, Uthumphon Phisai and Rasi Salai.

The district is divided into 18 sub-districts (tambons), which are further subdivided into 166 villages (mubans).

Missing numbers are tambons which now form the districts Wang Hin and Phayu.