p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa[5] followed by modification that involve addition of N-acetylglucosamine residues,[6] followed by association with other complex proteins.

Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells.

The protein encoded by this gene is a member of the FG repeat containing nucleoporins and is localized to the nuclear pore central plug.

Multiple transcript variants of this gene encode a single protein isoform.

p62 is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.