Ore Run begins in Davidson Township, near the northern edge of the East Branch Fishing Creek watershed.

[3] The discharge of Ore Run during average flow conditions is 481 gallons per minute.

During average flow conditions, the water quality of the stream is "severe", a rating worse than "very poor".

[2] Ore Run is considered by the Pennsylvania Department of Environmental Protection to be impaired by atmospheric deposition due to metals and pH, as is its unnamed tributary.

[3] The elevation near the mouth of Ore Run is 1,893 feet (577 m) above sea level.

[4] The lower reaches of Ore Run flow over rock of the Huntley Mountain Formation.

The upper reaches of the stream flow over rock of the Burgoon Sandstone formation.