1K6M520718639ENSG00000158571ENSMUSG00000025271P16118P70266NM_001271804NM_001271805NM_002625NM_001374175NP_001258733NP_001258734NP_002616NP_0013611046-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.

[5][6] This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes.

The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains.

Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

This article on a gene on the human X chromosome and/or its associated protein is a stub.