[4] Pardaxin shows a significantly lower hemolytic activity towards human red blood cells compared to melittin.
[6] The carpet mechanism is when a high density of peptides accumulates on the target membrane surface.
[7] The presence of anionic lipids or cholesterol was found to reduce the peptide's ability to disrupt bilayers.
It results in severe struggling, mouth paralysis, and temporary increase of urea leakage in the gills.
Research into creating a commercial shark repellent using pardaxin was discontinued because it dilutes in the water too quickly.
[8] Pardaxin inhibits proliferation and induces apoptosis of human cancer cell lines.
[9] Pardaxin initiates caspase-dependent and caspase-independent apoptosis in human cervical carcinoma cells.