Ponca Creek is a stream that flows from southern South Dakota and into northern Nebraska.

It flows into the Missouri River 6 miles (9.7 km) northwest of Niobrara.

Ponca Creek starts out going east, then takes a southeast direction, which continues until around Bristow, Nebraska, where it turns east again until it flows into the Missouri River.

[1] The towns in the Ponca Creek watershed in South Dakota are Colome, Dallas, Gregory, Burke, Herrick, and St. Charles.

The towns along Ponca Creek in Nebraska are Anoka, Spencer, Bristow, Lynch, Monowi, and Verdel.