Porosome

This could only be possible if the vesicle were to temporarily establish continuity with the cell plasma membrane, expel a portion of its contents, then detach, reseal, and withdraw into the cytosol (endocytose).

When a secretory vesicle containing v-SNARE docks at the porosome base containing t-SNARE, membrane continuity (ring complex) is formed between the two.

[5] Generally, the porosomes are opened and closed by actin, however, neurons require a fast response therefore they have central plugs that open to release contents and close to stop the release (the composition of the central plug is yet to be discovered).

[7] The neuronal porosome proteome has been solved, providing the possible molecular architecture and the complete composition of the machinery.

[8] The porosome was discovered in the early to mid-1990s by a team led by Professor Bhanu Pratap Jena at Yale University School of Medicine, using atomic force microscopy.