It is classified under the Ministry of Public Health as a regional hospital.

It has a CPIRD Medical Education Center which trains doctors for the Faculty of Medicine of Mahasarakham University.

[1] The foundation stone of Roi Et Hospital was laid on 5 September 1940 on the grounds of the Old Suea Pa Club.

The building was completed and opened to the public on 24 June 1941.

[2] In 2009, the hospital made an agreement to train medical students and act as a clinical teaching hospital for the Faculty of Medicine, Mahasarakham University under the Collaborative Project to Increase Production of Rural Doctors (CPIRD) program.