Sierra Leone competed at the 2022 Commonwealth Games held in Birmingham, England.

[1] This was Sierra Leone's 13th appearance at the Commonwealth Games.

Joshua Wyse and Hafsatu Kamara served as the country's opening ceremony flagbearers.

[2] The following is the list of number of competitors participating at the Games per sport/discipline.

[3] Sierra Leone was awarded a bipartite quota in the men's C3–5 event in para-table tennis.