[4] Side effects may include vomiting, joint pain, mood changes, psychosis, and ringing in the ears.

[6] Sodium thiosulfate then serves as a sulfur donor for the conversion of cyanide to the nontoxic thiocyanate, catalyzed by the enzyme rhodanase.

[12] In September 2022, the U.S. Food and Drug Administration (FDA) approved sodium thiosulfate under the brand name Pedmark to lessen the risk of ototoxicity and hearing loss in infant, child, and adolescent cancer patients receiving the chemotherapy medication cisplatin.

[2] There is a small amount of evidence supporting the use of sodium thiosulfate to counteract calciphylaxis, the calcification of blood vessels that may occur in hemodialysis patients with end-stage kidney disease.

[17][18] Sodium thiosulfate has been observed to help in the treatment of a rare systemic fibrosis condition caused by gadolinium-based contrast media in patients with kidney failure.

[19] The compound can also be used to measure the volume of extracellular body fluid and the renal glomerular filtration rate.

[23] Side effects may include vomiting, joint pain, mood changes, psychosis, and ringing in the ears.