The term is usually reserved for large-scale alterations of DNA such as chromosomal translocations and deletions and not applied to point mutations.
[3] In neurons of the human brain, somatic recombination occurs in the gene that encodes the amyloid precursor protein APP.
[6] These findings suggest that repair of some types of DNA damage requires a recombinational process that was defective in the mutants studied.
In nature, plants are continuously exposed to UV-B (280–320 nm) radiation, a component of sunlight that damages the DNA of somatic cells.
In A. thaliana, homologous recombination appears to be directly involved in repairing CPD damage.