219931233979ENSG00000162341ENSMUSG00000048677Q8NHX9Q8BWC0NM_139075NM_146206NP_620714NP_666318Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene.

[6] TPC2 is homologous to TPC1, the best characterized member of the TPC family.

The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories.

[7][8] The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands.

Genetic knockout and pharmacological inhibition experiments demonstrate that the two-pore channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice.