Approximately 0.4 miles (0.64 km) from SR 107, the route crosses the Nolichucky River.

It continues to the community of Washington College, where Bailey Bridge Road ends and SR 353 becomes Old State Route 34.

It continues northeast through rural areas to pass through Telford.

It meets its northern terminus in Jonesborough, an intersection with SR 81 southwest of downtown.

In addition, this was the first of two state highways in Tennessee to bear this designation.