Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in nattō and in fermented cocoa beans.

[1] In an observational study, tetramethylpyrazine was the dominant volatile organic compound in one sourdough starter.

Its biosynthesis involves amination of acetoin, the latter derived from pyruvate.

[3] It exhibits potential nootropic and antiinflammatory activities in rats.

[4][5] This article about a heterocyclic compound is a stub.