With the opening of a rough wagon road to the source of the Tioga River, New England colonists poured over the Allegheny Mountains.

Tioga County resembled upstate New York more than it did eastern Pennsylvania, as its population primarily consisted of colonists from New England.

[5] Developers and land speculators laid out roads, established post routes, erected public buildings, and invited people to move there.

In the late 19th and early 20th centuries, the county accepted more immigrants from Ireland, Germany and eastern Europe, who came to work in the coal mines.

It has a warm-summer humid continental climate (Dfb) and average monthly temperatures in Wellsboro range from 22.8 °F in January to 68.2 °F in July.

[19] In 2020, despite the state's slight leftward swing, the county swung further right to give Donald Trump the best Republican result since 1956.

In 2006, Rick Santorum and Lynn Swann both had significant victories in Tioga County despite their defeats statewide.

The following boroughs and townships are located in Tioga County: Census-designated places are geographical areas designated by the U.S. Census Bureau for the purposes of compiling demographic data.

Tioga County is historically home to several ghost towns for a variety of reasons, chiefly the decline of the lumber and coal industry.

Some small hamlets, such as Mardin and Olde Corner, who relied on Rural Free Delivery for trade met their downfall.