On November 21, 1992, a very strong cold-core low was located over southeastern New Mexico; in nearby El Paso, mid-level temperatures of −31 °C (−24 °F) were recorded.

Strong wind flow in advance of these features led to the northward transport of warm, moist air from the Gulf of Mexico and into the Southern United States.

The cold-core low progressed northeastward from western Texas toward the eastern Great Lakes region as the tornado outbreak unfolded.

This moist and unstable environment, combined with very strong wind shear, promoted the development of an intense squall line and isolated supercells ahead of it, contributing to multiple tornadoes in the Greater Houston area on the afternoon of November 21.

As the squall line spread eastward the next day, an intense low-level jet contributed to provide favorable wind profiles, abundant moisture, and a sufficiently unstable airmass.

As such, the line of thunderstorms maintained vigor as it moved eastward across the Gulf Coast, while discrete supercells continued to form to its east.

The tornado entered Rankin County and struck the south side of Florence as it moved through a mobile home park at that location.

The tornado then crossed into Leake County and struck the community of Pine Tree, where one person was killed in a mobile home.