A total of at least 484 people were killed during the entire outbreak sequence by at least 38 different tornadoes which struck Texas, Oklahoma, Kansas, Nebraska, Kentucky, Iowa, Illinois, Michigan, Missouri, Pennsylvania, New Jersey and Maryland.

[7][10] Bodies were found up to 400 yards (1,200 ft) from their home sites, and a trunk lid was carried for 35 miles (56 km).

[12] A powerful F5 tornado, estimated to have been more than 2 miles (3.2 km) wide, tore through the towns of Seneca, Oneida, Reserve and Sabetha, Kansas.

[7] The tornado continued into Nebraska, where four people died and damage occurred on the south side of Falls City.

Late during the evening hours of May 25, an F5 tornado touched down in Eastern Michigan and moved northeast for about 30 miles (48 km).

Twenty-two people were killed in Ortonville, ten in Oakwood, three in Thomas, four north of Oxford and three in Whigville with others in rural areas.

[12][18] The third deadliest tornado in United States history struck the Greater St. Louis area in both Missouri and Illinois.

This violent tornado killed at least 255 people (though one estimate placed the death toll at greater than 400), injured at least 1,000 more, and caused more than $10 million in damages.

It was one of at least 18 tornadoes to occur that day[19] At least 137 people died as the tornado traversed the core of the downtown area, leaving a continuous, one-mile-wide (1.6 km) swath of destroyed homes, schools, saloons, factories, mills, churches, parks, and railroad yards in its wake.

Numerous trees were downed at the 36-acre (0.15 km2) Lafayette Park, and a barometer recorded a drop to 26.74 inHg (906 hPa) at this location.

Uncounted others may have died on boats on the river, which could have swept their bodies downriver where they could not be recorded in the official death toll.