Due to the death of Antonio Puerta, the second leg of Sevilla's game against AEK Athens was postponed until 3 September.

Based on paragraph 6.05 in the regulations for the current season, if two or more teams are equal on points on completion of the group matches, the following criteria are applied to determine the rankings:[6] Sevilla and Slavia Prague made their debut appearance in the group stage.

In the knockout stage, teams played against each other over two legs on a home-and-away basis, except for the one-match final.

Due to a stadium clash with the match between Milan and Arsenal, the second leg of Internazionale's tie against Liverpool was held on 11 March.

Cristiano Ronaldo had given the eventual victors the lead after 26 minutes, only for Frank Lampard to equalise immediately before half-time.

Ryan Giggs came on as a substitute late in the second half to make his 759th appearance for Manchester United, a new club record.

A melée involving most of the 22 players ensued midway through the second half of extra time, with Didier Drogba being sent off for a slap on Nemanja Vidić right in front of the referee.

However, Chelsea's captain lost his footing as he went to kick the ball,[9] and his shot hit the post.

Ryan Giggs stepped up for United's seventh penalty, and scored, before Edwin van der Sar saved the following kick from Nicolas Anelka to crown Manchester United as the champions of Europe for the third time.

As winners of the competition, Manchester United went on to represent UEFA at the 2008 FIFA Club World Cup.