From there it runs primarily northwest as it passes Signal Mountain, and later Walden Ridge before entering Dunlap, where it turns northeast along Tennessee State Route 28.

From that point on it returns towards the northwest one more time as it winds through the woods surrounding the Sgt.

Finally in Static, the road runs along the Tennessee-Kentucky border where it makes a sharp turn at the northern terminus of TN 111 before entering Kentucky.

[2] At the state capital of Frankfort, it becomes a four-lane highway, then skirts Lawrenceburg, Harrodsburg, and Danville.

South of Dunnville it climbs onto the Eastern Pennyroyal Plateau and cuts through Russell Springs and Jamestown.

In the county US 127 runs through sinkhole plains along the escarpment that marks the western edge of the Cumberland Plateau, creating scenic views.

US 127 serves several cities and rural communities along the extreme western edge of Ohio, including Cincinnati, New Miami, Seven Mile, Somerville, Camden, Eaton, Greenville, Celina, Van Wert, Paulding and Bryan.

Prior to 2002, US 127 ran from I-69 north of East Lansing southerly to the Ohio border near Hudson, a total of 83 miles (134 km).

In 2002, the terminus was moved to an intersection with I-75 south of Grayling in Crawford County, Michigan, replacing all of US 27 north of Lansing.