U.S. Route 54 (US 54) is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois.

The highway serves as a major freeway for the Metro area's network, running north–south along the city's eastern slope of the Franklin Mountains range.

The highway runs through the city for approximately 20 miles (32 km) before reaching the New Mexico state line.

It also serves as a military highway to connect Fort Bliss in El Paso to Holloman Air Force Base in Alamogordo, New Mexico (via U.S. Route 70).

Exiting Vaughn, US 60 splits off to the southeast, and the route continues northeast to Santa Rosa where it becomes concurrent with Interstate 40.

The highway re-enters the Texas Panhandle just beyond Nara Visa, New Mexico, and continues northeast for 92 miles (148 km) to the Oklahoma border.

At Pratt, the Union Pacific railroad tracks which paralleled the highway for over 600 miles (970 km) from El Paso turn to the northeast (towards Topeka) and leave US 54.

From Kingman to Garden Plain in Sedgwick County it is a freeway but becomes an at-grade expressway as it passes through Goddard and approaches Wichita.

Upgrading of Kellogg Avenue from a surface arterial to a freeway has been underway since the mid-1980s, with the latest interchange project opening in late 2019.

The road gets its name from Milo Bailey Kellogg, a shopkeeper and Civil War veteran who was the city's first civilian postmaster in 1870.

Just north of the bridge, it splits passing through Fulton, crossing Interstate 70 at Kingdom City, bypassing Mexico, sharing a concurrency with Highway 19 through Laddonia, passing just north of Vandalia, and ultimately crossing the Mississippi River via the Champ Clark Bridge into Illinois at Louisiana.

In the state of Illinois, U.S. 54 runs from the Champ Clark Bridge over the Mississippi River to its terminus at Interstate 72 southwest of Griggsville.

That same year, the section of road that once carried Illinois Route 54 through Springfield is no longer designated as a numbered highway.