Larray hosted the show from a party bus in Los Angeles alongside special guest Issa Twaimz.

MrBeast's Team Seas fundraising initiative to clean oceans, rivers and beaches was highlighted during a special segment of the show.

[3][4] The 11th Streamy Awards featured the musical performances of the following artists:[3][4][5] The nominees were announced on October 20, 2021.

[6][7] Winners were announced during the digital ceremony on December 11, hosted by Larray from a party bus in Los Angeles.

[8] International Creator of the Year winner Mythpat praised the Streamys' use of an independent judging panel rather than voting, saying "It is not always about the number of followers but about the quality and type of content.