The 1990–91 Xavier Musketeers men's basketball team represented Xavier University from Cincinnati, Ohio in the 1990–91 season.

Led by head coach Pete Gillen, the Musketeers finished with a 22–10 record (11–3 MCC), won the MCC regular season and conference tournament titles, and received an automatic bid to the NCAA tournament as the #14 seed in the Midwest region.

In the NCAA tournament, the Musketeers defeated #3 seed Nebraska,[1] then lost to #11 seed Connecticut in the second round.

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