The 2005–06 Xavier Musketeers men's basketball team represented Xavier University in the 2005–06 college basketball season.

They were led by head coach Sean Miller in his second season at Xavier.

The Musketeers were members of the Atlantic 10 Conference and played their home games at the Cintas Center.

The Musketeers won four games in four days to capture the A-10 tournament title and secure the conference's automatic bid to the NCAA tournament.

14 seed in the Oakland region, Xavier lost to No.