The 2000–01 Xavier Musketeers men's basketball team represented Xavier University from Cincinnati, Ohio during the 2000–01 season.

Led by head coach Skip Prosser, the Musketeers finished 21–8 (12–4 A10) in the regular season, and won the Atlantic 10 tournament.

In the NCAA tournament, the Musketeers were beaten by No.

6 seed Notre Dame in the opening round.

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