The 1991–92 season saw Sampdoria compete in this season's editions of the Serie A, Coppa Italia, and European Cup.

The club reached the 1992 European Cup final only to suffer a 1–0 loss in extra time to Barcelona.

In the league, Sampdoria finished tied for sixth with Parma.

Due to Sampdoria's failure to secure European football, championship-winning coach Vujadin Boškov left his job.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.