The regiment served in all the wars of the Savoyard state until 1798 when it was disbanded due to Revolutionary France occupying Piedmont and forcing Charles Emmanuel IV of Sardinia to abdicate the throne in favor of the Piedmontese Republic.

The brigade also fought in the Second Italian War of Independence, during which the 1st Regiment was awarded a Bronze Medal of Military Valor for its conduct in the Battle of San Martino.

At the time the 1st Infantry Regiment consisted of three battalions, each of which fielded four fusilier companies and one machine gun section.

The brigade fought on the Italian front in World War I and the 1st Infantry Regiment "Re" earned its second Silver Medal of Military Valor.

[6][7] With the 1986 reform the Trieste Troops Command was disbanded on 1 October 1986 and the 1st Motorized Infantry Battalion "San Giusto" was transferred to the Mechanized Brigade "Vittorio Veneto".

With the end of the Cold War the "Vittorio Veneto" was disbanded on 31 July 1991 and the 1st Battalion "San Giusto" was transferred to the 5th Army Corps.