The 2010 Copa Petrobras Santiago was a professional tennis tournament played on hard courts.

It was the fourth edition of the tournament which was part of the 2010 ATP Challenger Tour.

The following players received wildcards into the singles main draw: The following players received a special entrant into the singles main draw: The following players received an alternate into the singles main draw: The following players received entry from the qualifying draw: Fabio Fognini def.

Paul Capdeville, 6–2, 7–6(2) Daniel Muñoz de la Nava / Rubén Ramírez Hidalgo def.

Nikola Ćirić / Goran Tošić, 6–4, 6–2