The 2010 Natomas Men's Professional Tennis Tournament was a professional tennis tournament played on hard courts.

It was the sixth edition of the tournament which was part of the 2010 ATP Challenger Tour.

It took place in Sacramento, United States between 4 and 11 October 2010.

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: John Millman def.

Robert Kendrick, 6–3, 6–2 Rik de Voest / Izak van der Merwe def.