The 2010 President's Cup was a professional tennis tournament played on outdoor hard courts.

It was the fourth edition of the tournament which was part of the 2010 ATP Challenger Tour.

It took place in Astana, Kazakhstan between 1 and 7 November 2010.

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: Ivan Dodig def.

Igor Kunitsyn, 6–4, 6–3 Colin Fleming / Ross Hutchins def.