The 2010 Open de Rennes was a professional tennis tournament played on hard courts.

It was the fifth edition of the tournament which was part of the 2010 ATP Challenger Tour.

The following players received wildcards into the singles main draw: The following players received entry as a Special Exempt into the singles main draw: The following players received entry from the qualifying draw: Marc Gicquel def.

Stéphane Bohli, 7–6(8–6), 4–6, 6–1 Scott Lipsky / David Martin def.

Denis Gremelmayr / Björn Phau, 6–4, 5–7, [12–10]