The season covers the period from 1 July 2021 to 30 June 2022.

[10] Crawley's first match was away to the previous season's National League play-off winners, Hartlepool United which they lost 1–0 after a late winner from Gavan Holohan.

[20] The club then faced League One side Gillingham in the first round of the EFL Cup and the away side went ahead in the 3rd minute after Gerald Sithole scored in "controversial circumstances".

[21] Crawley equalised in the 55th minute when Sam Ashford tapped in from close range and after a Daniel Phillips volley put the visitors ahead for the second time in stoppage time, Archie Davies equalised for the hosts on the 90+7th minute to take the match to a penalty shoot-out.

[24] Crawley were drawn at home to Tranmere Rovers in the first round.