[2] The league format allows participating franchises to rent their place to another team, so some clubs compete with a different name than the one registered with the FMF.
[3] NOTE: Puerto Aventuras (registered as Tulum) participated in the first half of the season, but withdrew from the league in January 2022 due to financial problems.
[3] NOTE: Deportivo Yurécuaro was announced as a member of the group, however on September 29, 2021, the club withdrew from the league voluntarily.
[3] NOTE: Atlético ECCA was announced as a team member of the group, however on September 29, 2021, it was expelled from the League for not fulfilling its obligations as an affiliate.
[3] NOTE: Camaroneros de Escuinapa participated in the first half of the season, but withdrew from the league in February 2022 due to unknown reasons.
[3] NOTE: Bravos de Nuevo Laredo participated in the first half of the season, but withdrew from the league in January 2022 due to financial problems.
Eliminations will be held according to the average obtained by each team, being ordered from best to worst by their percentage throughout the season.
The two losing clubs in the zone finals played a game to win a place in the Liga Premier – Serie B.
The two winning clubs from the zone finals played a match to determine the league champion.
The match was played on 3 June 2022 at the Estadio Ciudad de los Deportes, Mexico City.