The season covers the period from July 2021 to 30 June 2022.

On 12 March 2022, Macclesfield secured the championship and promotion to the NPL Division One following a 4–0 home win over Ashton Athletic.

Source: https://www.nwcfl.com/league-tables.php Macclesfield's league fixtures for the first half of the season were announced on 2 July 2021.

[5] The fixtures for the second half of the season were announced on 28 September 2021.

[7] Macclesfield were drawn away to Winterton Rangers in the first qualifying round.