In addition to the domestic league, Vitesse participated in this season's editions of the KNVB Cup and the inaugural UEFA Europa Conference League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Last updated: 29 May 2022 Source: Soccerway Source: Eredivisie The league fixtures were announced on 11 June 2021.

The draw for the knockout round play-offs was held on 13 December 2021.