In October, the club's uptick in form continued as they won four of their five Championship fixtures, beating Blackburn Rovers (home), Reading (away), local rivals Preston North End and newly relegated Sheffield United (away).

They lost 5–0 at already relegated Peterborough United, a result for which Neil Critchley and captain Chris Maxwell apologised to the travelling fans.

Blackpool announced they would have friendly matches against Squires Gate,[3] Southport,[3] Newport County,[3] Rangers,[4] Carlisle United,[3] Burnley,[5] Bamber Bridge[3] and Morecambe[3] as part of the club's pre-season preparations.

[8] Former Scotland international Stuart McCall joined the club as assistant head coach to Neil Critchley on 22 July 2021, replacing the departed Colin Calderwood.

[11] Blackpool's visit to nearby Squires Gate on 9 July ended in a 7–0 victory for the Tangerines, the goals coming from seven different players: Harrison, Mariette, Matshazi, Francis, Bange, Yelegon and Nyame.

Pre-season continued with a 1–1 draw at Morecambe on 31 July[17] (the visitors' goal coming from CJ Hamilton) and concluded with a 4–1 defeat at Premier League champions Manchester City on 3 August.

[24] Blackpool made the long trip to Bournemouth on 21 August, and found themselves two goals down inside twenty minutes after a double from Dominic Solanke.

Goals from James Husband and Jerry Yates (penalty) levelled matters,[25] giving the visitors their second point from a possible twelve since the start of the league campaign.

Three days later, Blackpool exited the EFL Cup at the second-round stage after losing 3–2 at home to Sunderland, whose Aiden O'Brien rounded out his hat-trick with a 92nd-minute winner.

[27] On transfer-deadline day, 31 August, Blackpool brought in four players: Jordan Gabriel (returning after being on loan at the club the previous season) in a permanent, four-year deal, while Ryan Wintle (Cardiff City), Dujon Sterling (Chelsea) and Owen Dale (Crewe Alexandra) joined on loan.

[34] A trip to Hull City resulted in a 1–1 draw, after Blackpool led for over half the game and despite the hosts being reduced to ten men with twenty minutes remaining.

He pulled his hamstring shortly afterwards, and his substitute Jerry Yates double the hosts' lead twenty minutes later.

Ben Brereton halved Rovers' deficit five minutes into the second half, but Blackpool held on for their fourth victory in their last six League fixtures.

[37] An unbeaten run of four games came to an end at the City Ground on 16 October as Nottingham Forest won their third Championship fixture in a row.

[39] Blackpool finished October with a third-straight victory, defeating Sheffield United at Bramall Lane by a single goal.

Keshi Anderson found the net for the second-consecutive match as the visitors climbed five places to sixth with the three points.

[50] A 3–1 victory over Peterborough United on 18 December lifted the Seasiders five places to 12th, although several matches were postponed after a COVID-19 outbreak across the country.

[53] 2022 was rung in with a single-goal victory over Hull City at Bloomfield Road, Gary Madine's penalty just after the half-hour mark proving decisive.

Blackpool exited the FA Cup at the first hurdle, after losing 2–1 at Hartlepool United on 8 January in a third-round tie.

The following day, midfielder Tayt Trusty joined Radcliffe on loan, linking up with his Blackpool teammate Jack Moore.

On 13 January, Owen Dale, having briefly returned to Crewe at the end of his four-month loan spell, made his move to Blackpool permanent.

[68] Blackpool made it ten points out of a possible twelve over their last four matches with a 3–1 home victory over Bristol City on 5 February.

[73] A midweek visit to the capital to face QPR saw the Tangerines returning home with a defeat, after conceding a goal to Luke Amos in the final minute of normal time.

After going behind, the Seasiders came back to win 4–1, with goals from Marvin Ekpiteta, Gary Madine, Shayne Lavery and Josh Bowler.

[76] On 12 March, Blackpool attained three consecutive league victories for the second time in the campaign with a single-goal scoreline at home Swansea City.

[80] A third defeat in four matches, this time at West Bromwich Albion, was followed by a 6–1 victory over Birmingham City at Bloomfield Road on 18 April.

Jake Beesley, on his first start at home, scored twice, with the other four goals coming from CJ Hamilton, Kenny Dougall (his first since the play-off final of the previous season), a penalty from Jerry Yates and a 35-yard free-kick from Callum Connolly.

[82] On 23 April, Blackpool drew 1–1 at Luton Town, Gary Madine scoring from the penalty spot for the visitors.

After the match, both Neil Critchley and captain Chris Maxwell apologised to the travelling fans for what was described as their "worst display" of the season.

Contract options were exercised on goalkeeper Stuart Moore, defenders Richard Keogh and Jordan Thorniley, midfielders Keshi Anderson and Josh Bowler, and forwards Ewan Bange and Brad Holmes.