The season started on 6 November 2021 and ended in May 2022.
The league will also see the introduction of B Teams by Olympiacos, PAOK, AEK Athens and Panathinaikos.
Panachaiki, Ialysos, Santorini 2020, Orfeas Xanthi, Doxa Drama, Panionios,[1] withdrew from the championship.
Promoted from Gamma Ethniki B Teams
Veria and Levadiakos played a 2 game title play-off on 8 and 15 May 2022.