The 2021 Campeonato Goiano (officially the Campeonato Goiano de Profissionais da 1ª Divisão – Edição 2021) was the 78th edition of Goiás's top professional football league organized by FGF.

[1] The competition counted with the return of Itumbiara and Jataiense (teams promoted from the 2020 Campeonato Goiano da Divisão de Accesso) that occupied the two places of the two 2020 relegated teams.

Due to the worsening of the COVID-19 pandemic in Brazil, the Government of Goiás suspended the Campeonato Goiano between 16 and 30 March 2021.

Tied 2–2 on aggregate, Grêmio Anápolis defeated Vila Nova on penalties 5–4 winning the Campeonato Goiano for the first time.

If the score was level, a penalty shoot-out would be used to determine the winners.