The 2021 Copa Verde was the eighth edition of the football competition held in Brazil.

Featuring 24 clubs, Acre, Amazonas, Distrito Federal, Espírito Santo, Mato Grosso do Sul and Pará have two vacancies; Amapá, Goiás, Mato Grosso, Rondônia, Roraima and Tocantins with one each.

The others six berths was set according to CBF ranking.

[1] In the finals, Remo defeated Vila Nova 4–2 on penalties after tied 0–0 on aggregate to win their first title and a place in the third round of the 2022 Copa do Brasil.

[5] Tied 0–0 on aggregate, Remo won on penalties.