[2] The draw for the first and second rounds was held on 2 March 2021, 15:00 at CBF headquarters in Rio de Janeiro.
[3] Teams were seeded by their CBF ranking (shown in parentheses).
In the first round, each tie was played on a single-legged basis.
The lower-ranked team hosted the match.
If tied after 90 minutes, the higher-ranked team would automatically advance to second round.