Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

The draw for the group stage was held on 9 April 2021, 12:00 PYST (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay.

The draw for the round of 16 was held on 1 June 2021, 12:00 PYST (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay.

[31] The draw for the third round was held on 23 April 2021 at CBF headquarters in Rio de Janeiro.

[36] Palmeiras qualified for the 2021 FIFA Club World Cup by winning the 2021 Copa Libertadores.