Atlético Mineiro defeated Athletico Paranaense 6–1 on aggregate in the finals to win their second title.

[3] The schedule of the competition is as follows:[9] The draw for the first and second rounds was held on 2 March 2021, 15:00 at CBF headquarters in Rio de Janeiro.

If the aggregate score was level, the second-leg match would go straight to the penalty shoot-out to determine the winners.

If the aggregate score was level, the second-leg match would go straight to the penalty shoot-out to determine the winners.

[12] The 16 qualified teams were drawn in a single group (CBF ranking shown in parentheses).

The draw for the quarter-finals was held on 6 August 2021, 15:00 at CBF headquarters in Rio de Janeiro.

The draw to determine the home-and-away teams for both legs was held on 22 September 2021, 15:00 at CBF headquarters in Rio de Janeiro.

The draw to determine the home-and-away teams for both legs was held on 4 November 2021, 15:00 at CBF headquarters in Rio de Janeiro.