2022 Chicago Fire FC season

The Fire would begin with an unbeaten record in their first four games (2-0-2), but would start a 10-game winless run where the club went 0-7-3 following their 3–1 victory over Sporting Kansas City on March 19.

Following an international break from May 29 until June 17, the Fire then went 6-3-1 over their next ten games, which ultimately led them to a 2-5-3 record to finish the season.

The club also lost to Union Omaha on penalties in the Third Round of the Open Cup, their worst ever performance in the competition.

Despite failing to make the playoffs, goalkeeper Gabriel Slonina set the club record for clean sheets in a season with 12 following the Fire's 0–0 draw with the Columbus Crew on September 3.

Slonina would be sold to Chelsea on August 2 for a club record fee, with a loan back for the remainder of the season.