The game, featuring all-star teams from Major League Soccer (MLS) and Liga MX, took place on August 10, 2022, at Allianz Field in Saint Paul, Minnesota.

It was primarily dark gray with a light purple trim and two jock tags referencing the state of Minnesota.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[8] Juan Escobar, Guido Pizarro, Luis Quiñones and Víctor Guzmán were called up as replacements for Dória, Diego Barbosa, Jordan Carrillo and Ángel Mena.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

The 2022 All-Star Game marked the return of "Goalie Wars", a head-to-head competition between goalkeepers, which was not televised and involved four MLS Next Pro players.