The team finished 2nd in the Eastern Conference standings during the regular season with 68 points.

[2] Memphis 901 qualified for the USL Championship Playoffs and were eliminated at home in the Eastern Conference Semifinals by the Tampa Bay Rowdies.

[3] The 2022 USL Championship season schedule for the club was announced on January 12, 2022.

[6][7] Win Draw Loss Upcoming fixture Unless otherwise noted, all times in Central time Memphis 901 FC entered the 2022 US Open Cup in the 2nd round with the rest of the USLC teams.

[8] Per United Soccer League and club policies, terms of the deals do not get disclosed.